However, it would be best to have a veterinarian collect a skin scraping to examine under a microscope and determine whether skin irritation is caused by demodectic or sarcoptic mites, as the causes and treatments differ between the two types. Dogs with normal MDR1 genes can usually tolerate oral dosages as high as 2,500 mcg/kg of body weight before signs of toxicity are seen, while dogs with two copies of the defective MDR1 gene can tolerate only up to 100 mcg/kg of oral ivermectin. Simparica Trio Intestinal Worms & Heartworm Treatment for Dogs. I am so excited. Each tablet is formulated to provide minimum dosages of 0.54 mg/lb (1.2 mg/kg) sarolaner, 0.011 mg/lb (24 g/kg) moxidectin, and 2.27 mg/lb (5 mg/kg) pyrantel (as pamoate salt). This gene specifically codes for P-glycoprotein, which is responsible for transporting certain drugs out of the brain. I love that it quickly kills adult fleas andfour kinds of ticks: American dog tick, brown dog tick, lone star tick, and black-legged tick. enough to have 4 dogs like I do! I was bummed to read its the safest since I dont want him to have it every again (a little off balance shortly after and salivating) but later he had an episode with fixed eyes, stuck in a strange position, stiff muscles, blind, he had a heart rate half of what it should have been and a head tremor. My border collie/lab mix has a major seizure yesterday and has no history of seizures before this. Hi Emily, do you know if panacure is a safe wormer? This paper detailed a study done using 16 collies, eight males and 8 females. I have to state the disclaimer that Im not a vet just someone who took a Research and Publishing class in college. I know youre very particular about the genetic health of your Collies, and I admire your breeding program. Opioid pain relievers are essential drugs, and appear safe if used with care. After logging in you can close it and return to this page. In September of 2018, the FDA issued a warning to all users of Bravecto (fluralaner), Nexgard (afoxalaner), and Simparica (sarolaner). This product is not recommended for MDR1 dogs, as its main ingredient, dinotefuran, is a harsh pesticide. Submit a story, ask a question, or just say hi; Emily would love to hear from you. Im glad you found this information helpful. If youre going the oral tablet route, Credelio is one I personally feel comfortable with! Simparica Trio works against the same ticks as Nexgard and also protects your dog from heartworms, hookworms, and roundworms. According to a thorough study conducted on MDR1-affected dogs, Interceptor and its more affordable generic, MilbeGuard, rank high in ML safety due to their use of the compound called milbemycin oxime. Since I recommend being careful about using Simparica, I would be even more careful about using the more potent Simparica Trio. Ill list all the options I looked into (including several Ive personally tried), along with whether theyre considered safe to use, use with caution, or a complete no-no. From the time that the collar went on the market in 2012 until 2020, the EPA (Environmental Protection Agency) received 1,698 reports of deceased pets. If you click on combination medications in the table of contents at the beginning of the article and read the section on Advantage Multi, youll find that Ive given it a caution rating along with reasons for that rating. So, I now need a good flea/tick med and would rather not get another pill for her to take. We do eat it! Seven Collies sound like a lot of work but also very wonderful! Sarolaner had been approved in 2016 to treat flea and ticks, moxidectin . Please log in again. If you think about it, come back here and let me and other readers know what worked best for you! Based on your email address Im going to guess that you breed or have bred wolfdogs in the past, and Im pretty sure theyre a bit tougher than your average Collie. I think this is a couple years old. Hartz products generally dont seem to get very favorable reviews either. (357 reviews) Simparica. We have always used Frontline Plus, but it has recently started causing dandruff on our dog, and it makes his coat greasy. I asked the vet for an alternative and was recommended Seresto collar or Vectra 3D. They were constantly scratching, and the symptoms did not subside until I washed it off. Interceptor is the go-to heartworm preventive for many Collie parents. I gave her Simparica 5 weeks ago for the first time. The oral chew contains a specially optimised trio of ingredients for . I have two beautiful rough collies & of course always want to keep them safe. . The effects of the mutation vary in severity, depending on whether the dog carries one or two copies of the mutation. Revolution and Stronghold even tested safe over the recommended monthly dosage for dogs with the MDR1 gene, and they hold the distinction of being the only heartworm meds that did not produce any negative drug reactions. Any suggestions? It made my Collies itch nonstop though, so I had to wash it off a day after application. Vectra is a rather strong product that I wont personally recommend, as so many dogs in the Collie family have sensitivities. Its worth making a phone call to see what they would recommend for your pup. Vectras brag is that it repels and kills fleas, five kinds of ticks, flies, mosquitoes, and mites; however, its use is not worth its risk. ? Components Species Test Results Silica colloidal, Ph. Turns out it is also used for the treatment and prevention of roundworms and lungworm nemotodes in dogs, according to Vet Shop Max. Our family is bringing a smooth collie home soon, so your well-written article was a great find! Thank you for your article. Thanks for your efforts to help! Personally, my Roughs have sensitive skin plus I have a household cat, so Id try Frontline Gold first. Personally, I would be concerned about missing a daily dose. Positive feedback keeps me writing! That averages out to about 212 deaths per year. The parasite protections that target multiple parasites with just one topical application or administration of a pill are extremely appealing due to their convenience. My dog (6 years old) has been using monthly Simparica since I got him. These people consider it a bad idea to give any Collie a harsh medication such as Heartgard, even if a genetic test reveals a dog to be normal/normal (clear) of the MDR1 gene. I have a unique situation. These three are listed as a new group of drugs called Isoxazolines, and are neurotoxins. However, the safety of Interceptor Plus has not been evaluated for pregnant or lactating dogs, and it is not recommended for cats. Roxie has never been tested, but she is Dashs niece so probably also mutant/normal if I were to guess. According to the product description, side effects as a result of Trifexis are rare, but can be as severe as seizures or even a coma. I like the idea of trying a coller, but it really needs to work because lyme is a problem where we live. All dogs treated with SIMPARICA TRIO were negative for D. immitis antigen and blood microfilariae at study completion on day 330. Simparica Trio is the first and only product that combines sarolaner, moxidectin and pyrantel in each treatment to help prevent heartworm disease, kill fleas before they can lay eggs, kill 5 types of ticks, treat and prevent flea infestations and treat and control roundworms and hookworms. It is the first drug that combined three active ingredients - sarolaner, moxidectin, and pyrantel. My Vet told me Trifexis was safe to give them. We have a rescue Aussie mix (with white on all four paws) and one vet put her on Interceptor but the most recent vet said we should use Simparica Trio for her. Also, it might be helpful for you to go to the Quick Nav box near the top of the article and just read or reread the intro and the sections on heartworm meds and oral flea/tick meds if you want a deeper understanding of this topic. Dinotefuran in particular is a strong pesticide, and all 3 of those ingredients combined are harsh on sensitive skin. He had been taking the it for about 2-3 months. Some parts of the U.S. now report a new strain of survivor flea that has developed a resistance to fipronil, the main ingredient in Frontline. My personal vet is knowledgeable of the MDR1 gene mutation (now also referred to as the ABCB1 mutation), and he recommended Interceptor to me for my mutant/normal Collies. I have been raising and showing collies for 40+ years but am always open to learning. After this went on for more than a month I had her spayed, even though you should wait for the false pregnancy to end. No treatment-related clinical signs were observed. Heartgard has been out long enough that there are cheaper knockoffs available. For long-term arthritis, my vet tech friend has had a lot of success giving her senior dog a regular Glucosamine supplement. It will make your dog smell absolutely yummy while protecting them from fleas, ticks, black flies, and mosquitoes. But Ive given it a caution designation as it should not be given in combination with heartworm meds and is not safe for dogs who are at risk for seizures. Hi Emily I am currently fostering 3 rescued puppy mill border collie females with sarcoptic mange. Happy to help! I do not know if my auss is a carrier for the mdr1 gene, and I told the vet about this and they double checked and said that the drugs in simparica trio should be fine for her. From an MDR1 standpoint, Simparica is *technically* safe; but I am leery of it considering the FDA warning about isoxazolines ("-laner" medications) I discussed in the article. Its simpler to identify medicines by their components, since many of them are essentially the same thing marketed under different brand names. Thank you. It is approved for use on puppies at least 3 pounds in weight and 7 weeks of age, cats, and even ferrets. Simparica Trio Chewable Tablets for Dogs works to prevent heartworms as well as treat lone star ticks, black-legged ticks, Gulf Coast ticks, American dog ticks, brown dog ticks, fleas, roundworms, and adult hookworms. But I do think K9 Advantix is a good choice for Collies who arent overly sensitive. Is Simparica trio safe for dogs with the MDR1 gene? These can come in a few different forms: monthly spot-on, a disposable collar, or a spray. . Im trying to find out if this is safe for her. If you are able to keep your dogs separated from your cats for 24hrs, the added protection against mosquitoes that K9 Advantix II provides from the possible diseases they carry seems like a greater pro to con ratio. After her first heat she went into a false pregnancy. Many veterinary clinics keep some in stock for their clients, and it is also available at online stores like 1-800-PET-MEDS or Chewy. I found some good information on the Cyphenothrin in Parastar Plus in this article. . We gave her the first dose in late February and there were no adverse side effects for Sugar. Are you referring to Advantage Multi, Advantage II, or a different product I didnt cover in the article? It is formulated to repel and kill fleas and 4 kinds of ticks on contact, provide protection from lice, and treat/control sarcoptic mange. Australian Shepherds, along with several other mostly collie-type breeds, can carry a genetic mutation that makes them sensitive to certain drugs. The MDR1 test will determine if your pet is affected by a mutation in the MDR1 gene. I realized that I just replied to another comment from you Im sorry you and your doubly sensitive girl are having such trouble trying to find products that work for her! I found a paper on the web written with credits to several vets. Giardia can be passed to and cause diarrhea in humans. And use same collar for a few months. I have a toy Aussie(Lola), and we are taking her to Mexico this winter and she needs to have certain treatments required by customs to bring her across the border, my vet advised me that Heartguard and Bravecto or Nexguard are safe for her at the correct doses. We had a wonderful smooth girl for years and while many of the medication names here sound familiar, I cant remember what we gave her. 1 x 40mg tablet for 22.1 to 44 pounds. She had a severe reaction with diarrhea, drooling, depression etc. Im sincerely grateful!! Dogs with the MDR1 mutation can be 200 times more sensitive to the drugs than dogs that do not have this mutation. If you have one of those rare dogs who is just going to react to every heartworm medication (fingers and toes crossed thats not the case), then you might want to consider frequent heartworm tests as an alternative to regular heartworm treatment. Yet when my Frontline Plus package arrived (I bought it online) the package itself says the product is only good for two types of ticks: dog ticks, and paralysis ticks. PARSIPPANY, N.J. - January 04, 2022 - Zoetis today announced that the U.S. Food and Drug Administration (FDA) has approved a new label indication for Simparica Trio (sarolaner, moxidectin, and pyrantel chewable tablets) for the prevention of Borrelia burgdorferi infections as a direct result of . Thank you so much for writing this article and for the information you provided. 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