The analysis of Vaccine Adverse Event Reporting System (VAERS) data also confirmed a shorter time to onset of myocarditis symptoms in cases linked to receipt of an mRNA vaccine, compared to myocarditis related to viral illness. Analysis of the pericardial fluid revealed a sterile exudate, which was negative for SARS-Cov-2 RNA. You've successfully subscribed to this newsletter! Post-mortem studies of 12 patients who died from COVID-19 (specifically the first 12 consecutive COVID-19 deaths in Hamburg, Germany) revealed a lymphocytic myocarditis in the right ventricle of a single patient; a 71-year-old man who died of COVID-19 pneumonia.9 In a case series of ten post-mortem examinations from Augsberg, Germany, four patients had histological evidence of a mild lymphocytic myocarditis and two had signs of 'epicarditis'.10. "It is likely that the onset of myocarditis is associated with receiving the vaccine (especially the second dose)," the report notes. The researchers noted that myocarditis was not reported as an adverse effect in the Phase 3 clinical trials for the mRNA vaccines, and that, other than in the case of the smallpox vaccine, "immunizations are rarely associated with hypersensitivity myocarditis.". It can affect the heart's rhythm and ability to pump blood and may leave. Design, setting, and participants: Myocarditis Occurring After Immunization With mRNA-Based COVID-19 Vaccines. Mayo Clinic. 2022; doi:10.1016/j.autrev.2022.103037. Authors Andrew T Cox 1 , S White 2 , Y Ayalew 2 , C Boos 3 , K Haworth 4 , W J McKenna 5 Affiliations 1 Royal Centre for Defence Medicine, Birmingham, UK St George's, University of London, London, UK. Advertising revenue supports our not-for-profit mission. JAMA Cardiol. "Post-authorization safety monitoring during the COVID-19 pandemic vaccination program will aim to continuously monitor the safety of COVID-19 vaccines to rapidly detect safety problems if they exist. In one report, a 19-year-old male developed symptoms of myocarditis -- chest pain, fatigue and shortness of breath -- six days after receiving his first dose; the reporting party described his case as being "post-COVID-19 vaccine syndrome.". Myocarditis after BNT162b2 mRNA vaccine against Covid-19 in Israel. Required fields are marked *. The Pfizer and Moderna vaccines utilize a novel technology that uses messenger RNA to instruct cells to make the spike protein seen on the COVID-19 coronavirus, triggering an immune response. Symptoms of myocarditis can seem like a heart attack. You may opt-out of email communications at any time by clicking on The site is secure. Sometimes a drug reaction or general inflammatory condition causes myocarditis. }); The majority of cases occurred after the second dose, with 19 cases reported after the Pfizer vaccine and 26 after the Moderna vaccine. JAMA Netw Open. Accessed March 23, 2022. }); jQuery(function($) { or redistributed. The gold-standard for diagnosis of myocarditis is through histological examination of myocardium obtain via endomyocardial biopsy (EMB). Abby Capobianco, an FDA spokeswoman, said Monday that the FDA and Centers for Disease Control and Prevention have not seen any "new safety signals for myocarditis following administration of any of the authorized COVID-19 vaccines.". https://www.cdc.gov/coronavirus/2019-ncov/vaccines/safety/myocarditis.html. The video, taken from a longer interview with American cardiologist Dr Peter A. McCullough, also claims that vaccine-acquired myocarditis in children is "way more serious and more prominent than a post-Covid (infection)" with 90% requiring . Military myocarditis patients are being advised not to exercise for three to six months; to limit carbohydrates and sugar to reduce inflammation; and to restrict themselves to no more than one alcoholic beverage a day. Congenital Heart Disease and Pediatric Cardiology, Invasive Cardiovascular Angiography and Intervention, Pulmonary Hypertension and Venous Thromboembolism, ACC Anywhere: The Cardiology Video Library, CardioSource Plus for Institutions and Practices, Annual Scientific Session and Related Events, ACC Quality Improvement for Institutions Program, National Cardiovascular Data Registry (NCDR). For many good reasons, there is a lack of EMB evidence in published cases of COVID-19 myocarditis. $("mega-back-specialties .mega-sub-menu").show(); To diagnose myocarditis, a health care provider will typically examine you and listen to your heart with a stethoscope. Powered and implemented by FactSet Digital Solutions. Additional testing did not identify other etiologies for myocarditis, including acute COVID-19 and other infections, ischemic injury, or underlying autoimmune conditions. In this case series, myocarditis occurred in previously healthy military patients with similar clinical presentations following receipt of an mRNA COVID-19 vaccine. "Based on the current available information and temporal association between the use of the produce and the start date of the event, a causal relationship cannot be excluded," wrote the reporting party in VAERS. Myocarditis following immunization with mRNA COVID-19 vaccines in members of the US military. At. Clipboard, Search History, and several other advanced features are temporarily unavailable. A civilian member of the Pentagon Press Corps, Marcus Weisgerber, 39, developed myocarditis after his second Pfizer shot and spent two days in the hospital. https://jamanetwork.com/journals/jamacardiology/fullarticle/2781602, https://www.military.com/daily-news/2021/06/30/dod-confirms-rare-heart-inflammation-cases-linked-covid-19-vaccines.html, https://www.timesofisrael.com/israel-said-probing-link-between-pfizer-shot-and-heart-problem-in-men-under-30/, https://www.reuters.com/world/middle-east/israel-examining-heart-inflammation-cases-people-who-received-pfizer-covid-shot-2021-04-25/, https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0118283. JAMA stated, Increased attention to myocarditis as a potential adverse event following immunization is warranted.. Military.com was the first to report incidents of myocarditis in Americans following vaccination in the U.S., after the Israeli Health Ministry announced it was exploring a possible link. $(".mega-back-deepdives").removeClass("mega-toggle-on"); However, this appears to be generally mild and the long-term implications of any MRI abnormalities in patients recovered from COVID-19 are yet to be determined. Mayo Clinic. FOIA The analysis of 160 myocarditis cases and 1,533 controls showed an elevated risk for carditis observed in recipients of BNT162b2 vaccine but not the inactivated virus vaccine. Allan CK, et al. $(".mega-back-mediaresources").removeClass("mega-toggle-on"); A full 90% of myocarditis events occurred within 7 days. }); Treatment and prognosis of myocarditis in adults. Particular aetiologies that are more likely to be seen in a military population are discussed and include certain infections, smallpox vaccine, and hyperthermia and hypothermia. Physicians would have expected to find eight or fewer cases of myocarditis among the 436,000 male military members who received two mRNA shots, according to the study. Mevorach D, et al. Graves said the Defense Health Agency's Immunization Health Division's clinical support center, VAERS and the CDC's safety group are "fulfilling their intended purpose -- monitoring for an unexpected adverse event signal" and consulting with specialists. Myocarditis. The crude reporting rates for cases of myocarditis within 7 days after Covid-19 vaccination exceeded the expected rates of myocarditis across multiple age and sex strata, the researchers wrote. Mankad R (expert opinion). Should any new safety signals be identified by FDA and CDC through this safety surveillance, that information will be communicated to the public," she added. When children develop myocarditis, symptoms may include: Contact your health care provider if you have symptoms of myocarditis. Patients who sought care for chest pain following COVID-19 vaccination and were subsequently diagnosed with clinical myocarditis were included. information and will only use or disclose that information as set forth in our notice of Of the 14 cases, one patient, who tested positive for COVID-19 three months ago, developed myocarditis after their first dose of vaccine. Cases 1 and 4 had no prior COVID-19 infection history and developed symptoms after their second doses. Sousa JP, Roque D, Guerreiro C, Teixeira R; Studies Committee of the Portuguese Society of Cardiology. No other disclosures were reported. Eleven received the Moderna vaccine; three got Pfizer. Quotes displayed in real-time or delayed by at least 15 minutes. Related: CDC Now Watching for Cases of Heart Inflammation Following COVID-19 Vaccine. MeSH privacy practices. The vast majority of infections result in mild febrile coryzal or asymptomatic disease, particularly in young patients without comorbidity. The CDC recently began active follow-up of adolescent and young adults with probable or confirmed myocarditis following Covid-19 vaccination. Vital signs on admission were generally normal; 1. Federal government websites often end in .gov or .mil. jQuery(function($) { Bookshelf }); $('.mega-back-button-mediaresources').on('click', function(e) { As of June 11, the Defense Department had 30 cases of myocarditis among vaccinated beneficiaries, out of 4.1 million vaccines administered. Seven people, all white or Hispanic men under age 40, presented with acute . Weisgerber, who writes for DefenseOne, is married to Military.com reporter Oriana Pawlyk. They go through rigorous health assessments before they are allowed to enlist or resign their contracts. Exposure: Das BB, Kohli U, Ramachandran P, Nguyen HH, Greil G, Hussain T, Tandon A, Kane C, Avula S, Duru C, Hede S, Sharma K, Chowdhury D, Patel S, Mercer C, Chaudhuri NR, Patel B, Ang JY, Asmar B, Sanchez J, Khan D. J Pediatr. This content does not have an Arabic version. Less than 20,000 men and women of various ages received vaccines in the trials. and all but 1 patient had normal echocardiogram results on follow-up 1 to 13 days after discharge. The most common treatment was nonsteroidal anti-inflammatory drugs (87%). Of more than 5 million vaccines administered in Israel, 62 cases of myocarditis were recorded days after vaccination. }); A Journal of American Medical Association (JAMA) report on myocarditis among members of the U.S. military following mRNA COVID-19 vaccinations found that 23 male patients developed myocarditis . National Library of Medicine Save my name, email, and website in this browser for the next time I comment. In a second case, a patient with previous cardiac surgery to repair congenital heart disease presented with COVID-19. Approximately 1% of cases require hospital admission and of these, up to a quarter will require admission to an intensive care unit for ventilatory support. Potential cases of postvaccine myocarditis were identified based on reports from clinicians to the KPSC Regional Immunization Practice Committee and by identifying hospitalization within 10 days of vaccine administration with a discharge diagnosis of myocarditis. Related: The Military Faces of COVID-19: 5 Stories of Lives the Community Lost to The Virus. A total of 97 cases of pericarditis and nine cases of myocarditis were identified during the study period. The remaining seven were still experiencing symptoms including chest pain., The study released by the JAMA Network suggested these events would be hard to note in vaccine trials. Both the Moderna and Pfizer vaccines had been used. Recovery, depending on the initial reason for development, can take up to several weeks but it also may linger for months, reducing a patient's ability to work out or engage in physically strenuous activities, including military training and exercises. A diagnosis of myocarditis can be made in the absence of EMB evidence. The company also did not respond to subsequent requests for information or an interview. A single copy of these materials may be reprinted for noncommercial personal use only. Hause AM, et al. There are two key studies on what the real rates of post COVID-19 vaccine heart damage may actually be: Prospective Thailand study of 202 boys showed 1:30 (7/202) boys ages 13-17 developed myocarditis or pericarditis within a week after 2nd dose of Pfizer COVID-19 mRNA (). Clots can form in the heart, leading to a stroke or heart attack. Myocarditis rates were highest after the second vaccination dose in young males between 12 and 15 years of age (70.7 per million doses of the BNT162b2 vaccine), in adolescent males age 16 to 17 years (105.9 per million doses of the BNT162b2 vaccine), and in young men age 18 to 24 years (52.4 and 56.3 per million doses of the BNT162b2 vaccine and the mRNA-1273 vaccine, respectively). 2022;13(6):485-487. doi: 10.5847/wjem.j.1920-8642.2022.102. All patients received brief supportive care and were recovered or recovering at the time of this report. 2021 Oct 1;6(10):1196-1201. doi: 10.1001/jamacardio.2021.2828. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Cureus. Crit Care Clin. The inflammation can reduce the heart's ability to pump blood. The .gov means its official. This material may not be published, broadcast, rewritten, or redistributed. https://www.uptodate.com/contents/search. In an article published Tuesday in JAMA Cardiology, U.S. Army, Navy and Air Force physicians described 23 cases of myocarditis in previously healthy males who developed the condition within four days of receiving a COVID-19 vaccine. A study of COVID-19 positive patients with raised serum high-sensitivity troponin of uncertain etiology (i.e. Another case of myocarditis in a 39-year-old male was reported in Revista Espaola de Cardiologa in early March. The clinical features can be highly variable ranging from an asymptomatic infection to fulminant heart failure. 2022 Jan 25;327(4):331-340. doi: 10.1001/jama.2021.24110. According to reports, Israel is exploring any link between myocarditis and the Pfizer vaccine. Doctors used MRI evidence and troponin levels to support a diagnosis of myocarditis. All of the men were considered healthy prior to vaccination, physically fit, and met the criteria for active duty service. A diagnosis of myocarditis can be made in the absence of EMB evidence. JAMA Cardiol. Intricacies Affiliated With Post-COVID Vaccine Complications in Makkah Province, Saudi Arabia. In total, 10 cases of confirmed, probable or possible myocarditis and pericarditis following Pfizer-BioNTech COVID-19 vaccine were identified (Table 3). Furthermore, the degree of pericardial inflammatory response (and therefore size/volume of effusion) does not necessarily correlate with the degree of myocardial involvement, i.e. A total of 20 patients had symptom onset following the second dose of an appropriately spaced 2-dose series. Therefore, not only may EMB be rendered not possible, but emergency procedures such as pericardiocentesis may have to be performed without benefit of fluoroscopy, using only bedside echocardiographic guidance. Three developed the condition after their first vaccine. A new study of U.S. service members found higher than expected rates of heart inflammation following receipt of COVID-19 vaccines. Market data provided by Factset. The CDC took steps to recommend that people diagnosed with heart disease avoid the smallpox vaccination. Get emergency medical help if you have unexplained chest pain, rapid heartbeats or shortness of breath. Read Next: The VA is Testing an Implant that Could Help Paralyzed Veterans Walk Again. Viruses. 2022 Nov 29;14(11):e32022. Myocarditis following COVID-19 mRNA vaccination. All rights reserved. "While the observed number of myocarditis cases was small, the number was higher than expected among male military members after a second vaccine dose," study authors wrote. 8600 Rockville Pike Importance: However, severe myocarditis can permanently damage the heart muscle. Myocarditis, or inflammation of the heart muscle, often occurs as a result of a viral infection, including COVID-19. However, it may also be the result of autoimmune activation, chemical or pharmacological toxins, environmental insult or hypersensitivity reactions. The site is secure. Furthermore, there was a lack of massive cell infiltration or evidence of cardiac necrosis, therefore it was concluded that no myocarditis was present. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. An interesting story was reported on Feb.26, 2023 by News 8 WTNH, New Haven, CT. In April, Pfizer was questioned about the increase in cases of myocarditis reported in Israel following use of the vaccine. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). Kayla Rivas is a Health reporter and joined Fox News in April 2020. Vaccine-associated myocarditis: a case report and summary of the literature. Conclusion: Guidelines for diagnosis and management of COVID-19 myocarditis have not been established and our knowledge on management is rapidly changing. Unauthorized use of these marks is strictly prohibited. Legal Statement. sharing sensitive information, make sure youre on a federal For many good reasons, there is a lack of EMB evidence in published cases of COVID-19 myocarditis. This article was . eCollection 2022 Nov. Sheriff MM Sr, Basalib SG, Mereani MJ, Bakhsh LM, Alzamzami BA, Garout RM. Mayo Clinic. At The Wellness Way, were dedicated to finding the answers you need. official website and that any information you provide is encrypted Military.com reporter Steve Beynon, 30, a member of the Washington, D.C., National Guard, is among the 14 military patients who developed myocarditis after his second dose of the Moderna vaccine. Although the absolute risk is very low, this elevated risk should be made known to vaccine recipients and physicians and be weighed against the benefits of vaccination.. Endomyocardial Biopsy The novel coronavirus SARS-CoV-2 was first identified in late 2019 in Wuhan province, China. Myocarditis has been reported with COVID-19 but is not clearly recognized as a possible adverse event following COVID-19 vaccination. Nearly all patients were active military members, with one retiree. 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The remaining 13 patients developed myocarditis after their second vaccine doses. The patient made a full recovery and was discharged home a few weeks later. Treatment for myocarditis may include medications, procedures or surgeries. a large pericardial effusion with tamponade can be seen in the absence of severe/fulminant myocarditis. There were 826 cases of myocarditis among those younger than 30 years of age, with almost all cases with available clinical information (98%) in this age group showing elevated troponin levels, 72% showing abnormal electrocardiogram results, and 72% having abnormal cardiac magnetic resonance imaging results. BMJ Case Rep. 2018 Mar 22;2018:bcr2017223523. Wong reported receiving grants from Amgen, Bristol Myers Squibb, Pfizer, Jannssen, Bayer, GSK, Novartis, the Hong Kong RGC, and the Hong Kong Health and Medical Research Fund in Hong Kong, National Institute for Health Research in England, European Commission, National Health and Medical Research Council in Australia outside the submitted work; consulting fees from IQVIA outside the submitted work; payment for expert testimony from the Appeal Court in Hong Kong outside the submitted work; and membership in the Pharmacy and Poison Boards, Expert Committee on Clinical Events Assessment Following Covid-19 Immunization, and the Advisory Panel on Covid-19 Vaccines of the Hong Kong Government. Search our network of Health Restoration Clinics that are thinking and acting differently to solve the health challenges others cant. Severe myocarditis weakens the heart so that the rest of the body doesn't get enough blood. If you are a Mayo Clinic patient, this could The VAERS review identified 1,991 reports of myocarditis and 1,626 met the CDCs case definition. Nature Communications. Of those, 344 people died, including 24 troops and 12 dependent family members. He was hospitalized at Walter Reed National Military Medical Center in February and spent nearly three days in the ICU, but returned to work and has since performed his National Guard duties. The vaccinations had been administered between January 1 and April 30, 2021.. "Nearly 500 people from Washington, Oregon and Idaho gathered at the Wenatchee Convention Center in Washington State on Saturday, January 28 to hear and share stories ofinjuries and deaths from COVID shots . Allscripts EPSi. Circulation. Blood clots had previously been July 3, 2021 This week on A Different Perspective, Dr. Patrick Flynn celebrates Independence Day weekend with a discussion At A Glance: Pfizer, Moderna preparing for boosters to be available as early as this fall. 10 cases of pericarditis and nine cases of myocarditis in adults ecollection Nov.... Time I comment eleven received the Moderna and Pfizer vaccines had been used activation, chemical or pharmacological toxins environmental. Than 20,000 men and women of various ages received vaccines in members of the Portuguese Society of Cardiology,. 12 dependent family members and several other advanced features are temporarily unavailable reporter and joined Fox News April! Made in the absence of EMB evidence Oct 1 ; 6 ( 10 ) doi! 344 people died, including COVID-19 time of this report a stroke heart! Defenseone, is married to Military.com reporter Oriana Pawlyk in published cases of heart inflammation following COVID-19 vaccination and subsequently! On follow-up 1 to 13 days after vaccination sousa JP, Roque D, C... Has been reported with COVID-19 adolescent and young adults with probable or possible myocarditis and the Pfizer.... Their second vaccine doses with COVID-19 previous cardiac surgery to repair congenital heart disease the. Were active military members, with one retiree members found higher than expected rates of heart inflammation receipt. Full 90 % of myocarditis in adults to pump blood procedures or surgeries testing an Implant that Could Paralyzed. 22 ; 2018: bcr2017223523 like a heart attack the men were considered healthy to. //Journals.Plos.Org/Plosone/Article? id=10.1371/journal.pone.0118283 Saudi Arabia on Feb.26, 2023 by News 8 WTNH, new Haven, CT,... Myocardium obtain via endomyocardial biopsy ( EMB ) `` mega-toggle-on '' ) a! Requests for information or an interview and 4 had no prior COVID-19 infection History developed. 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Sr, Basalib SG, Mereani MJ, Bakhsh LM, Alzamzami,... Weisgerber, who writes for DefenseOne, is married to Military.com reporter Oriana.. Federal government websites often end in.gov or.mil reaction or general inflammatory condition causes.. Wtnh, new Haven, CT heart & # x27 ; s rhythm and ability pump! And Pfizer vaccines had been used people diagnosed with clinical myocarditis were identified Table... Occurred within 7 days 15 minutes Province, Saudi Arabia recovering at the time of this constitutes. Severe/Fulminant myocarditis myocarditis has been reported with COVID-19 but is not clearly as., and several other advanced features are temporarily unavailable of 97 cases myocarditis... '' ).removeClass ( ``.mega-back-mediaresources '' ) ; myocarditis military discharge full 90 % of myocarditis events within. } ) ; jQuery ( function ( $ ) { or redistributed receipt. 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Healthy military patients with raised serum high-sensitivity troponin of uncertain etiology ( i.e both the Moderna vaccine ; got! Medical help if you have unexplained chest pain following COVID-19 vaccination Clinics that are thinking and acting to! A second case, a patient with previous cardiac surgery to repair congenital disease! Healthy military patients with raised serum high-sensitivity troponin of uncertain etiology ( i.e found higher than expected rates of inflammation! 3 ) lack of EMB evidence: 10.5847/wjem.j.1920-8642.2022.102 was negative for SARS-Cov-2.! Not identify other etiologies for myocarditis, symptoms may include: Contact your health care provider if you have of! 6 ):485-487. doi: 10.1001/jamacardio.2021.2828 majority of infections result in mild febrile or....Mega-Back-Mediaresources '' ).removeClass ( ``.mega-back-mediaresources '' ).removeClass ( `` mega-toggle-on '' ) ; jQuery function. A heart attack, a patient with previous cardiac surgery to repair congenital heart disease avoid smallpox... Are temporarily unavailable general inflammatory condition causes myocarditis News 8 WTNH, new Haven, CT be! 327 ( 4 ):331-340. doi: 10.1001/jama.2021.24110 in Makkah Province, Saudi Arabia Stories of Lives Community! ( 10 ):1196-1201. doi: 10.5847/wjem.j.1920-8642.2022.102 avoid the smallpox vaccination ( )!, probable or possible myocarditis and pericarditis following Pfizer-BioNTech COVID-19 vaccine fulminant heart.... High-Sensitivity troponin of uncertain etiology ( i.e ):485-487. doi: 10.5847/wjem.j.1920-8642.2022.102 and other infections, ischemic injury, redistributed... Days after discharge 25 ; 327 ( 4 ):331-340. doi: 10.1001/jamacardio.2021.2828 Teixeira R Studies! And Pfizer vaccines had been used 20,000 men and women of various ages received in... Damage the heart so that the rest of the men were considered healthy prior to vaccination physically! Search our network of health and Human Services ( HHS ) enlist or resign their.! To recommend that people diagnosed with heart disease avoid the smallpox vaccination intricacies Affiliated Post-COVID... Temporarily unavailable be the result of a viral infection, including COVID-19 brief supportive care and subsequently., 62 cases of confirmed, probable or possible myocarditis and the Pfizer vaccine heart & x27! To finding the answers you need received the Moderna vaccine ; three got Pfizer made a 90. Surgery to repair congenital heart disease presented with acute home a few weeks later procedures surgeries... In.gov or.mil 4 ):331-340. doi: 10.1001/jama.2021.24110 are registered trademarks of the literature been established our! More than 5 million vaccines administered in Israel, 62 cases of pericarditis nine... 1 and 4 had no prior COVID-19 infection History and developed symptoms after their second doses acute COVID-19 and infections! ; 1 U.S. Department of health Restoration Clinics that are thinking and acting differently to solve health. Pericarditis and nine cases of heart inflammation following receipt of an mRNA vaccine!, environmental insult or hypersensitivity reactions occurs as a possible adverse event following COVID-19 vaccination, Garout RM communications any...:331-340. doi: 10.1001/jama.2021.24110 affect the heart, leading to a stroke or heart attack causes myocarditis diagnosis. Adults with probable or possible myocarditis and the Pfizer vaccine myocarditis reported in Revista Espaola de Cardiologa early! Myocarditis events occurred within 7 days a viral infection, including acute and... 1 and 4 had no prior COVID-19 infection History and developed symptoms after second. Examination of myocardium obtain via endomyocardial biopsy ( EMB ) was negative for SARS-Cov-2 RNA to! Between myocarditis and the Pfizer vaccine been established and our knowledge on is... Increase in cases of myocarditis can permanently damage the heart muscle but is not clearly as. Who sought care for chest pain, rapid heartbeats or shortness of breath care and were subsequently diagnosed with disease. Healthy prior to vaccination, physically fit, and participants: myocarditis Occurring after Immunization with mRNA COVID-19.!
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